⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

December 1, 2025JACS AuOpen Access

Regioselective Glycosylation of Fluorine-18-Labeled Sorbitol for Enhanced Bacterial Detection In Vivo Using PET

Sang‐Hee Lee Jung Min Kim Marina López‐Álvarez Alexandre M. Sorlin Mohammad Yaqoob Bhat Joseph Blecha Robert R. Flavell Youngho Seo Joanne N. Engel Michael A. Ohliger David M. Wilson

View Full Paper

Ask AI

Bookmark

Share

Key Points

The research aims to improve bacterial detection using a novel PET tracer labeled with fluorine-18.
Regioselective glycosylation of sorbitol was performed to create a fluorine-18-labeled compound.
The performance of the PET tracer was evaluated in in vivo models to assess bacterial infection detection capabilities.
Fluorine-18-labeled sorbitol demonstrated significant improvement in detecting bacterial infections.
The tracer exhibited high translational potential for clinical applications.

Implication

Shows enhanced bacterial detection with fluorine-18-labeled sorbitol, indicating promising PET tracer potential.

Abstract

F]-FNT as a highly promising PET tracer with a high translational potential for detecting bacterial infection in vivo.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/6a20888055df6adc1bcd4d67 https://doi.org/10.1021/jacsau.5c01153

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Selective PET imaging of bacterial infection using a glycosylated 18F-fluorodeoxyglucose-derived tracerOriginal Research · 2026
218F-labelled gentiobiose as potential PET-radiotracer for specific bacterial imaging: precursor synthesis, radiolabelling and in vitro evaluation2024 · 2 citations
3Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [ <sup>18</sup> F]FDGOriginal Research · 2026
4A Novel Arene Trifluoromethyl-Based <sup>18</sup>F-Labeling Strategy for Enhanced Biomolecular Tracer Development in PET Imaging2025 · 3 citations
5Development and preclinical validation of 2-deoxy 2-[ <sup>18</sup> F]fluorocellobiose as an <i>Aspergillus</i> -specific PET tracer2024 · 3 citations