Key result
Long QT Syndrome was associated with prolonged atrial action potential durations and a higher incidence of polymorphic atrial tachyarrhythmias compared to controls (50% vs 0%; P<0.05).
Why the study?
Do patients with long QT syndrome have altered atrial electrophysiology and increased risk of atrial arrhythmias compared to controls?
Case-Control (n=31)
Do patients with long QT syndrome have altered atrial electrophysiology and increased risk of atrial arrhythmias compared to controls?
Absolute Event Rate: 50% vs 0%
p-value: p=< 0.05
Patients with long QT syndrome exhibit prolonged atrial action potentials and a specific polymorphic atrial tachyarrhythmia reminiscent of an atrial form of torsades de pointes.
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May indicate need for atrial monitoring in LQTS; leaves open prospective confirmation of clinical arrhythmia risk.
Kirchhof et al. (2003) conducted a case-control in Long QT Syndrome (n=31). Long QT Syndrome vs. Controls was evaluated on Polymorphic atrial tachyarrhythmias (polyAT) (p=< 0.05). Long QT Syndrome was associated with prolonged atrial action potential durations and a higher incidence of polymorphic atrial tachyarrhythmias compared to controls (50% vs 0%; P<0.05).
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