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April 1, 1992Circulation ResearchOpen Access

Beta-adrenergic modulation of fast inward sodium current in canine myocardium. Syncytial preparations versus isolated myocytes.

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Population

Canine myocardium preparations including syncytial Purkinje fibers, ventricular muscle preparations, and…

Comparison

Isoproterenol (ISO) 0.5-1.0 microM or 1 microM vs Different preparations and recording techniques

Design

Preclinical

Authors

GGGary A. GintantElectrophysiologyDLD W LiuHebei North University

Discussion

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Implication

Experimental conditions alter beta-adrenergic sodium current effects; leaves open physiological relevance of isolated myocyte data.

Structured PICO

P
Population
Canine myocardium preparations including syncytial Purkinje fibers, ventricular muscle preparations, and isolated ventricular myocytes
I
Intervention
Isoproterenol (ISO) 0.5-1.0 microM or 1 microM
C
Comparator
Different preparations (syncytial vs isolated) and recording techniques (microelectrodes vs patch pipettes)
O
Outcome
Alterations of the maximum rate of rise of the action potential upstroke (Vmax) as an index of changes of INasurrogate

The response of the fast inward sodium current to beta-adrenergic stimulation differs significantly between intact syncytial preparations and isolated myocytes, highlighting the impact of experimental conditions on electrophysiological measurements.

Cite This Study

Gintant et al. (1992) studied this question.

synapsesocial.com/papers/6a208889ee274fb2963e8964https://doi.org/10.1161/01.res.70.4.844
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes1988 · 61 citations
  2. 2Inhibition of cardiac Na+ currents by isoproterenol1990 · 69 citations
  3. 3Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential.1990 · 147 citations
  4. 4Two components of transient outward current in canine ventricular myocytes.1989 · 220 citations
  5. 5The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.1983 · 52 citations