Rabbit and syngeneic mouse antisera produced against solubilized membrane antigens from plasma‐cell tumors MOPC‐315 and MOPC‐460 recognize neoplastic plasma‐cell antigens that are not detectable in normal tissues. The rabbit antisera showed precipitating antibodies against two tumor‐associated antigens expressed in both MOPC‐315 and MOPC‐460 cells and unrelated to plasma‐cell‐specific antigens or myeloma proteins. These were called embryo (EM) antigen and A‐particle‐associated (Aa) antigen. The EM‐antigen seemed to be related to mitotic activity and was also expressed by a mouse adenocarcinoma and by mouse embryo cells. The Aa‐antigen was detected by immuno‐precipitation in all of nine different mouse tumors. Its purification by reverse immunoadsorption demonstrated that it consisted of two related components. Syngeneic mouse antisera showed precipitating antibodies against only part of the Aa‐antigen determinants recognized by rabbit antisera. Lastly, one mouse antiserum precipitated with an antigen of unique specificity detectable on MOPC‐315 only.
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Comoglio et al. (1973) studied this question.
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