Key result
Atrial septal aneurysm was associated with a significantly higher prevalence of supraventricular arrhythmias compared to healthy controls (43.9% vs 8.1%; P<0.001).
Why the study?
Does the presence of atrial septal aneurysm increase P-wave dispersion, signal-averaged P-wave duration, and the prevalence of supraventricular arrhythmias compared to healthy controls?
Case-Control (n=128)
Does the presence of atrial septal aneurysm increase P-wave dispersion, signal-averaged P-wave duration, and the prevalence of supraventricular arrhythmias compared to healthy controls?
Patients with atrial septal aneurysms have prolonged signal-averaged P-wave duration and P-wave dispersion, which may predict an increased prevalence of supraventricular arrhythmias.
Answers are grounded in this paper and cite their sources.
May indicate need for arrhythmia monitoring in atrial septal aneurysm; leaves open causal role and screening utility pending prospective data.
OBJECTIVE: The aim of the study was to investigate the relationship between atrial septal aneurysms (ASAs) and cardiac arrhythmias via signal-averaged P-wave duration (SAPWD) and P-wave dispersion (Pd). METHODS: Sixty-six patients with ASA served as the study group (group 1; 28 men and 38 women; mean age, 34 +/- 10 years) and 62 healthy volunteers served as the control group (group 2; 29 men and 33 women; mean age, 31 +/- 8 years) in the current study. ASAs were diagnosed by transthoracic echocardiography based on the criteria of a minimal aneurysmal base of > or =15 mm; and an excursion of > or =10 mm. All subjects were evaluated by 24-hour Holter monitoring, 12 lead body surface electrocardiogram for P-wave analysis, and signal-averaged electrocardiogram for P-wave duration (PWD). RESULTS: There was no significant difference between the study and control groups in terms of age, gender, left atrium diameter, and left ventricular ejection fraction. Supraventricular arrhythmias (SVAs) were detected in 29 patients with ASA (43.9%) and 5 controls (8.1%; P < 0.001). The mean Pd in patients with ASA was significantly longer compared to the control group (14.1 +/- 8 ms vs 7.0 +/- 2.9 ms; P < 0.001). Similarly, the mean SAPWD in group 1 was significantly longer compared to group 2 (127.4 +/- 17.6 ms vs 99.8 +/- 12.3 ms; P < 0.001). CONCLUSION: Prolonged SAPWD and Pd were determined to indicate electrical disturbances in the atrial myocardium, and predict the increase in the prevalence of SVA in patients with ASA.
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Deveci et al. (2010) conducted a case-control in Atrial septal aneurysm (n=128). Atrial septal aneurysm vs. Healthy volunteers was evaluated on Supraventricular arrhythmias (SVAs) (p=< 0.001). Atrial septal aneurysm was associated with a significantly higher prevalence of supraventricular arrhythmias compared to healthy controls (43.9% vs 8.1%; P<0.001).
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