Key result
Claudicating patients with peripheral artery disease exhibit impaired skeletal muscle arteriole endothelial function, associated with attenuated mitochondrial respiration and oxygen utilization.
Observational
Impaired microcirculatory and mitochondrial function contribute to compromised skeletal muscle oxygen delivery and utilization in claudicating patients with PAD.
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May implicate microvascular and mitochondrial targets in PAD; cross-sectional data leave causality and clinical utility open.
Park et al. (2022) conducted an observational in Peripheral artery disease (PAD) with claudication. Peripheral artery disease was evaluated on Skeletal muscle arteriole endothelial function, mitochondrial respiration, and oxygen utilization. Claudicating patients with peripheral artery disease exhibit impaired skeletal muscle arteriole endothelial function, associated with attenuated mitochondrial respiration and oxygen utilization.
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