March 25, 2022AJP Heart and Circulatory Physiology50 citationsOpen Access
Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease
Key Result
Claudicating patients with peripheral artery disease exhibit impaired skeletal muscle arteriole endothelial function, associated with attenuated mitochondrial respiration and oxygen utilization.
Study Design
Type
Observational
Structured PICO
P
Population
claudicating patients with peripheral artery disease (PAD)
O
Outcome
skeletal muscle arteriole endothelial function, mitochondrial respiration, and oxygen delivery and utilization capacitysurrogate
Impaired microcirculatory and mitochondrial function contribute to compromised skeletal muscle oxygen delivery and utilization in claudicating patients with PAD.
Abstract
Ex vivo skeletal muscle arteriole endothelial function is impaired in claudicating patients with PAD, and this is associated with attenuated skeletal muscle mitochondrial respiration. In vivo skeletal muscle oxygen delivery and utilization capacity is compromised in PAD, and this may be due to microcirculatory and mitochondrial dysfunction. These results suggest that targeting skeletal muscle arteriole function may lead to improvements in skeletal muscle mitochondrial respiration and oxygen delivery and utilization capacity in claudicating patients with PAD.