Key result
Altering temperature from 37°C to either 35°C (546 mg) or 39°C (896 mg) significantly decreased the α1-mediated vasocontractile response compared to 37°C (1478 mg; P<0.05).
Why the study?
Does altering temperature to 35°C or 39°C attenuate α1-mediated vasocontraction in human skeletal muscle feed arteries compared to 37°C?
Does altering temperature to 35°C or 39°C attenuate α1-mediated vasocontraction in human skeletal muscle feed arteries compared to 37°C?
p-value: p=<0.05
In human skeletal muscle feed arteries, α1-mediated vasocontraction exhibits an 'inverted U' response to temperature, being attenuated by both warming (39°C) and cooling (35°C).
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Animal data on temperature and α1-vasocontraction require human validation; leaves open whether inverted-U response applies to skeletal muscle feed arteries.
Ives et al. (2011) studied this question. Altered temperature (35°C and 39°C) vs. 37°C was evaluated on Vasocontractile response to 1 mM phenylephrine (PE) (p=<0.05). Altering temperature from 37°C to either 35°C (546 mg) or 39°C (896 mg) significantly decreased the α1-mediated vasocontractile response compared to 37°C (1478 mg; P<0.05).
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