Key result
Stimulation of smooth muscle cells with phenylephrine increased intracellular calcium in both smooth muscle and endothelial cells, a flux reduced by the gap junction uncoupler palmitoleic acid.
Population
Rat mesenteric arterial segment in vitro
Design
Preclinical
Authors
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No immediate clinical implications from rat arteries; leaves open gap junction calcium signaling in human vasoregulation.
Demonstrates calcium flux from smooth muscle cells to endothelial cells via gap junctions during alpha-1 adrenergic stimulation and vasomotion in rat mesenteric arteries.
Schuster et al. (2001) studied this question. Phenylephrine (PE) and palmitoleic acid was evaluated on Intracellular calcium concentration and artery diameter. Stimulation of smooth muscle cells with phenylephrine increased intracellular calcium in both smooth muscle and endothelial cells, a flux reduced by the gap junction uncoupler palmitoleic acid.
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