Key result
Among subjects with severe aortic stenosis, men had significantly higher aortic valve calcification scores than women (3646 vs 2433, p=0.001), regardless of racial background.
Why the study?
Prior data showing men have greater aortic valve calcification than women in severe aortic stenosis were derived largely from Caucasian populations and unverified in non-Caucasian subjects.
Does male gender associate with higher aortic valve calcification scores compared to female gender in a racially mixed population with severe aortic stenosis?
Observational (n=137)
No
Does male gender associate with higher aortic valve calcification scores compared to female gender in a racially mixed population with severe aortic stenosis?
Absolute Event Rate: 3646% vs 2433%
p-value: p=0.001
Men with severe aortic stenosis have significantly higher aortic valve calcium scores than women regardless of racial background, supporting the use of gender-specific AVC thresholds in diverse populations.
AVC scores differ by gender in severe AS regardless of race; extends prior observations to diverse cohorts but remains hypothesis-generating.
Aortic stenosis (AS) is common and increasing in prevalence as the population ages. Using computed tomography (CT) to quantify aortic valve calcification (AVC) it has been reported that men have greater degrees of calcification than women among subjects with severe AS. These data, however, were derived in largely Caucasian populations and have not been verified in non-Caucasian subjects. This retrospective study identified 137 patients with severe AS who underwent valve replacement and had CT scans within 6 months prior to surgery. AVC scores were compared between men and women, both in the entire sample and in racial subgroups. 52% of subjects were male and 62.8% were non-Caucasian. Mean AVC score for the entire cohort was 3062.08±2097.87 with a range of 428-13,089. Gender differences in aortic valve calcification were found to be statistically significant with an average AVC score of 3646±2422 in men and 2433±1453 in women (p=0.001). On multivariate analysis, gender remained significantly associated with AVC score both in the entire sample (p=0.014) and in the non-Caucasian subgroup (p=0.008). Mean AVA was significantly greater in males than females but this difference disappeared when AVA was indexed to BSA (p=0.719). AVA was not different between racial groups (p=0.369). In this research we observed that among subjects with severe AS men have higher AVC scores than women regardless of racial background. This is consistent with previous studies in predominantly Caucasian populations.
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Brito et al. (2020) conducted an observational in Severe aortic stenosis (n=137). Male gender vs. Female gender was evaluated on Aortic valve calcification (AVC) score (p=0.001). Among subjects with severe aortic stenosis, men had significantly higher aortic valve calcification scores than women (3646 vs 2433, p=0.001), regardless of racial background.
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