Key result
Heart rate variability low frequency and complexity indexes significantly correlated with uric acid, creatinine, hemoglobin, and platelet levels in third-trimester pregnancies.
Why the study?
What is the relationship between heart rate variability indexes and biochemical markers in normal, hypertensive, and preeclamptic third-trimester pregnancies?
Observational
What is the relationship between heart rate variability indexes and biochemical markers in normal, hypertensive, and preeclamptic third-trimester pregnancies?
Heart rate variability indexes, particularly low frequency spectral variables, correlate significantly with biochemical markers such as uric acid and creatinine in normal and hypertensive pregnancies.
May inform noninvasive monitoring in hypertensive pregnancies; leaves open clinical utility pending prospective validation.
BACKGROUND: In this study, we explored the correlations between heart rate variability indexes and some biochemical markers during the third trimester of normal, hypertensive, and preeclamptic pregnancies. METHODS AND RESULTS: The obtained indexes are associated with complexity and spectral variables calculated from short electrocardiographic records. CONCLUSIONS: Including all the subjects in the analysis, we found that complexity indexes are positively related with hemoglobin concentration in the pathologic group and uric acid blood levels whereas low frequency (LF) was negatively correlated with uric acid and creatinine concentration as well as positively correlated with platelet levels. The LF was the only spectral region with significant correlation. Through an independent analysis of groups, only significant correlations were found in normal and preeclamptic groups between LF and uric acid concentration and in normal and hypertensive groups for LF and creatinine blood levels.
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Tejera et al. (2011) conducted an observational in Normal, hypertensive, and preeclamptic pregnancies. Heart rate variability indexes was evaluated on Correlation with biochemical markers (hemoglobin, uric acid, creatinine, platelets). Heart rate variability low frequency and complexity indexes significantly correlated with uric acid, creatinine, hemoglobin, and platelet levels in third-trimester pregnancies.
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