Key result
Microalbuminuria levels showed a strong and statistically significant positive correlation with the severity of chronic obstructive pulmonary disease based on GOLD staging (r = 0.749, p < 0.001).
Why the study?
Microalbuminuria is a marker of endothelial dysfunction and cardiovascular risk that may be caused by hypoxemia in COPD, but its presence and relationship with COPD severity warrant study.
Cross-Sectional (n=67)
No
Effect estimate: r = 0.749
p-value: p=<0.001
Microalbuminuria levels increase with the severity of COPD, suggesting its potential utility as a biomarker for disease severity and cardiovascular risk in this population.
Microalbuminuria may track COPD severity; hypothesis-generating for biomarker utility pending prospective validation.
Background: Microalbuminuria is a marker of endothelial dysfunction and an important risk factor for cardiovascular diseases. Microalbuminuria may be seen due to hypoxemia in patients with chronic obstructive pulmonary disease (COPD). The objectives were to study the presence of microalbuminuria in patients with chronic obstructive pulmonary disease and to determine the relationship of microalbuminuria with severity of COPD using GOLD staging.Methods: The study was done on 68 patients of COPD. Urine spot albumin measurement, pulmonary function tests, spirometry and GOLD staging were done. Severity of COPD was assessed by GOLD staging. Pearson Co-relation test and ANOVA test were used for statistical analysis.Results: Statistical analysis showed that strong and statistically significant positive correlation of Microalbuminuria with GOLD staging(r =0.749, p = 0.001).Conclusions: Microalbuminuria(MAB) was found to increase in patients with increasing severity of COPD. Hence its potential role as a marker of severity of disease and in predicting risk of cardiovascular disease can be explored.
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Shashidhar et al. (2020) conducted a cross-sectional in Chronic obstructive pulmonary disease (n=67). COPD severity (GOLD staging) was evaluated on Correlation between microalbuminuria and severity of COPD using GOLD staging (r = 0.749, p=<0.001). Microalbuminuria levels showed a strong and statistically significant positive correlation with the severity of chronic obstructive pulmonary disease based on GOLD staging (r = 0.749, p < 0.001).
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