Population
C2C12 mouse skeletal muscle cell line
Comparison
Ionomycin and 12-O-tetradecanoylphorbol acetate vs Untreated controls or EGTA-treated controls
Design
Preclinical
Authors
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Hypothesis-generating for Ca2+/PKC control of Kir2.1 expression; leaves open translation to human cardiac electrophysiology.
Intracellular calcium and protein kinase C oppositely regulate IRK1 gene expression in mouse skeletal muscle by altering mRNA stability.
Shin et al. (1997) studied this question.
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