February 7, 1994FEBS Letters

Calcium influx blocks the skeletal muscle acetylcholine receptor α‐subunit gene in vivo

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Population

Denervated chick skeletal muscle

Comparison

Calcium-active drugs (L-channel… vs Electrostimulation

Design

Preclinical

Authors

CHChang‐Fen HuangJohns Hopkins University JSJakob SchmidtUniversity of Kassel

Discussion

Member takes

Implication

Calcium influx links depolarization to gene transcription in skeletal muscle; extends basic mechanisms but hypothesis-generating for clinical translation.

Structured PICO

Population

Denervated chick skeletal muscle

Intervention

Calcium-active drugs (L-channel agonist (-)Bay-K6844, calcium ionophore A23187, intracellular chelator BAPTA, calcium channel blockers D600 and nifedipine)

Comparator

Electrostimulation

Outcome

Transcriptional activity of the acetylcholine receptor alpha-subunit genesurrogate

Influx of extracellular calcium is an integral component of the membrane depolarization-receptor gene inactivation cascade in skeletal muscle.

Cite This Study

Huang et al. (1994) studied this question.

synapsesocial.com/papers/6a83f3b407bf35307a997247 https://doi.org/10.1016/0014-5793(94)80283-1

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Implication

Calcium influx links depolarization to gene transcription in skeletal muscle; extends basic mechanisms but hypothesis-generating for clinical translation.

Calcium influx blocks the skeletal muscle acetylcholine receptor α‐subunit gene in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calcium influx blocks the skeletal muscle acetylcholine receptor α‐subunit gene in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider