Population
Cultured rat dorsal root ganglion (DRG) neurones and guinea-pig cardiac myocytes
Comparison
Antipeptide antibody targeted at amino acids… vs Controls
Design
Preclinical
Authors
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Antibody-mediated alpha 1D L-type current inhibition shown in DRG neurons and cardiac myocytes; leaves open therapeutic potential pending in vivo validation.
The study demonstrates the presence of calcium channel alpha 1D subunits in rat DRG neurones and guinea-pig cardiac myocytes, and shows that targeted antibody binding attenuates L-type calcium channel currents.
Wyatt et al. (1997) studied this question.
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