December 9, 1997Proceedings of the National Academy of SciencesOpen Access

β subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line

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Population

Human epithelial kidney cells coexpressing alpha1A, alpha2delta with different beta calcium channel subunits…

Comparison

Coexpression of different beta subunits with… vs Different combinations of subunits

Design

Preclinical

Authors

HMHerman MorenoState University of New York BRBernardo RudySupélec RLRodolfo LlinásNew York University

Discussion

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Implication

Beta subunit dictates P-type blocker sensitivity in recombinant systems; leaves open translation to native channels or therapeutics.

Structured PICO

Population

Human epithelial kidney (HEK) cells coexpressing alpha1A, alpha2delta with different beta calcium channel subunits and green fluorescence protein

Intervention

Coexpression of different beta subunits (betaIb, beta2a, beta3) with alpha1A and alpha2delta

Comparator

Different combinations of subunits (e.g., alpha1A alone vs with beta subunits)

Outcome

Calcium current characteristics (inactivation rate, sensitivity to omega-Aga IVA and sFTX)surrogate

The beta subunit associated with the alpha1A subunit highly influences the specificity of calcium channel blockers and the biophysical properties of the channel.

Cite This Study

Moreno et al. (1997) studied this question.

synapsesocial.com/papers/6a20ffbd894b966f6186de01 https://doi.org/10.1073/pnas.94.25.14042

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β subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line

Discussion

Member takes

Implication

Structured PICO

Cite This Study

β subunits influence the biophysical and pharmacological differences between P- and Q-type calcium currents expressed in a mammalian cell line

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider