Key result
Co-expression of beta subunits with the alpha 1A Ca2+ channel caused a hyperpolarizing shift in voltage-dependent activation and inactivation in physiological Ca2+ compared to high Ba2+.
The modulation of alpha 1A Ca2+ channels by beta subunits differs between physiological Ca2+ and high Ba2+ concentrations, highlighting the importance of physiological conditions in electrophysiological studies.
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Highlights importance of physiological Ca²⁺ in beta modulation studies; leaves open native tissue and in vivo relevance.
Cens et al. (1996) studied this question. Co-expression of beta 1b, beta 2a, beta 3, or beta 4 subunit vs. Expression of alpha 1A alone was evaluated on Voltage-dependent activation and inactivation in 1.8 mM Ca2+ vs 40 mM Ba2+. Co-expression of beta subunits with the alpha 1A Ca2+ channel caused a hyperpolarizing shift in voltage-dependent activation and inactivation in physiological Ca2+ compared to high Ba2+.
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