April 30, 1999FEBS Letters

Regulation of Ca‐sensitive inactivation of a l‐type Ca2+ channel by specific domains of β subunits

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Population

Xenopus oocytes expressing the alpha1C subunit of the L-type Ca2+ channel

Design

Preclinical

Authors

TCThierry CensÉcole Nationale Supérieure de Chimie de Montpellier SRSophie RestituitoColumbia University PCPierre CharnetÉcole Nationale Supérieure de Chimie de Montpellier

Discussion

Member takes

Implication

Does not support changes in Ca2+ channel-targeted therapies; leaves open whether beta2a splice variants modulate Ca2+ entry in heart and brain.

Structured PICO

Population

Xenopus oocytes expressing the alpha1C subunit of the L-type Ca2+ channel

Intervention

Expression of beta subunit deletion mutants and chimeric constructs of beta1 and beta2 subunits

Outcome

Ca2+-dependent inactivation kinetics (Ca2+ current decays)surrogate

The amino-terminal region of the beta2a subunit is the major element regulating Ca2+-dependent inactivation kinetics of L-type Ca2+ channels, suggesting splice variants can specifically modulate Ca2+ entry in heart and brain regions.

Cite This Study

Cens et al. (1999) studied this question.

synapsesocial.com/papers/6a896f16e2cdaa7909622195 https://doi.org/10.1016/s0014-5793(99)00463-9

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Implication

Does not support changes in Ca2+ channel-targeted therapies; leaves open whether beta2a splice variants modulate Ca2+ entry in heart and brain.

Regulation of Ca‐sensitive inactivation of a l‐type Ca2+ channel by specific domains of β subunits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of Ca‐sensitive inactivation of a l‐type Ca2+ channel by specific domains of β subunits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider