March 1, 2002Journal of NeuroscienceOpen Access

Alternative Splicing of the β4Subunit Has α1Subunit Subtype-Specific Effects on Ca2+Channel Gating

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Population

Xenopus oocytes expressing human spinal cord-derived Ca2+ channel beta4 subunits and various alpha1 subunits

Comparison

Expression of beta4a subunit complexes vs Expression of beta4b subunit complexes

Design

Preclinical

Authors

THThomas D. HeltonArgonne National Laboratory WHWilliam A. HorneMichigan State University

Discussion

Member takes

Implication

Beta4 splicing effects on Ca channel gating remain preclinical; leaves open relevance to human cardiovascular excitability or arrhythmias.

Structured PICO

Population

Xenopus oocytes expressing human spinal cord-derived Ca2+ channel beta4 subunits (beta4a or beta4b) and various alpha1 subunits (alpha1A, alpha1B, alpha1C, alpha1E)

Intervention

Expression of beta4a subunit complexes

Comparator

Expression of beta4b subunit complexes

Outcome

Voltage dependence of activation and inactivation, and rate of inactivationsurrogate

Alternative splicing of the Ca2+ channel beta4 subunit has alpha1 subunit-specific effects on voltage-dependent gating parameters.

Cite This Study

Helton et al. (2002) studied this question.

synapsesocial.com/papers/6a83d47753408ed95e4d88bb https://doi.org/10.1523/jneurosci.22-05-01573.2002

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Implication

Beta4 splicing effects on Ca channel gating remain preclinical; leaves open relevance to human cardiovascular excitability or arrhythmias.

Alternative Splicing of the β4Subunit Has α1Subunit Subtype-Specific Effects on Ca2+Channel Gating

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Alternative Splicing of the β4Subunit Has α1Subunit Subtype-Specific Effects on Ca2+Channel Gating

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider