Key result
Expression of five beta2-subunit isoforms increased open probability, availability, and peak current of L-type calcium channels, with modulation correlating strongly with amino-terminal length.
The length of the amino terminus in cardiac beta2-subunits determines the extent of L-type calcium channel modulation, revealing a physiological mechanism for channel gating.
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Does not inform clinical calcium channel targeting; extends molecular understanding of cardiac beta2-isoform effects.
Herzig et al. (2007) studied this question. Five beta2-subunit isoforms (beta2a-e) was evaluated on Single L-type calcium channel current (open probability, availability, and peak current). Expression of five beta2-subunit isoforms increased open probability, availability, and peak current of L-type calcium channels, with modulation correlating strongly with amino-terminal length.
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