Molecular Determinants of β1Subunit-Induced Gating Modulation in Voltage-Dependent Na+Channels
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Population
Xenopus oocytes expressing recombinant human heart and human skeletal muscle voltage-gated Na+ channel alpha…
Comparison
Coexpression of beta 1 subunit vs Expression of alpha subunits alone
Design
Preclinical
Authors
Discussion
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Implication
No immediate clinical implications; extends mapping of beta1 interaction sites on Na channels for future studies.
Structured PICO
P
Population
Xenopus oocytes expressing recombinant human heart (hH1) and human skeletal muscle (hSkM1) voltage-gated Na+ channel alpha subunits and chimeric constructs
I
Intervention
Coexpression of beta 1 subunit (or chimeric beta subunits)
C
Comparator
Expression of alpha subunits alone (without beta 1 subunit)
O
Outcome
Changes in Na+ channel gating (time constants for onset of inactivation and recovery from inactivation, and fraction of fast-inactivating component)surrogate
The D1/S5-S6 and D4/S5-S6 loops in the alpha subunit and the extracellular domain of the beta 1 subunit are critical determinants of beta 1 subunit-induced gating modulation in voltage-gated Na+ channels.
Cite This Study
Makita et al. (1996) studied this question.
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