February 1, 1996Circulation Research
Multiple Domains Contribute to the Distinct Inactivation Properties of Human Heart and Skeletal Muscle Na+Channels
Population
Chimeric Na+ channels composed of segments from human heart and human skeletal muscle alpha-subunit isoforms
Comparison
Creation of chimeric channels exchanging… vs Background channel isoforms (hH1 and hSkM1)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May guide isoform-specific Na+ channel modulators; extends molecular insights but leaves clinical translation open.
Structured PICO
P
Population
Chimeric Na+ channels composed of segments from human heart (hH1) and human skeletal muscle (hSkM1) alpha-subunit isoforms
I
Intervention
Creation of chimeric channels exchanging cytoplasmic interdomain regions (ID1-2, ID2-3, and ID3-4) or approximately equal halves of the two channel isoforms
C
Comparator
Background channel isoforms (hH1 and hSkM1)
O
Outcome
Inactivation properties and response to coexpressed beta 1-subunitsurrogate
Multiple alpha-subunit domains contribute to the distinct inactivation properties of human heart and skeletal muscle Na+ channels.
Cite This Study
Makita et al. (1996) studied this question.