Key result
Human heart hH1 Na channels show slower kinetics and hyperpolarized activation versus skeletal and brain isoforms.
Human cardiac sodium channels exhibit distinct, slower gating kinetics and operate at more hyperpolarized voltages compared to skeletal muscle and neuronal isoforms.
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May refine cardiac excitability models; leaves open isoform-specific arrhythmia therapies pending human validation.
Michael E. O’Leary (1998) studied this question. Human heart (hH1) Na channels vs. Human skeletal muscle (hSkM1) and rat brain (rIIA) Na channels was evaluated on Activation and inactivation of whole-cell Na currents. Human heart (hH1) Na channels activate and inactivate at more hyperpolarized voltages and have slower kinetics of activation, inactivation, and recovery compared to skeletal muscle and brain isoforms.
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