Key result
Replacement of the C-terminal domain of Na v 1.2a with Na v 1.5 slowed inactivation ≈2-fold, highlighting the C terminus's role in differing inactivation rates of sodium channels.
Population
Brain Nav1.2a and cardiac Nav1.5 sodium channels
Comparison
Chimeric exchange or deletion of the C-terminal… vs Wild-type Nav1.2a and Nav1.5 channels
Design
Preclinical
Authors
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Does not yet alter channelopathy management; extends mechanistic insight into NaV isoform inactivation differences.
The C-terminal domain is primarily responsible for the differing rates of inactivation between brain and cardiac sodium channels.
Mantegazza et al. (2001) studied this question. Replacement of the C-terminal domain of Na v 1.2a with Na v 1.5 slowed inactivation ≈2-fold, highlighting the C terminus's role in differing inactivation rates of sodium channels.
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