Population
Rat brain IIA sodium channel expressed from cDNA encoding the sodium channel alpha subunit
Comparison
Mutations of the second and fourth conserved… vs Wild-type channel and channel with fast…
Design
Preclinical
Authors
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Animal sodium channel data extend inactivation models; leaves clinical translation to channelopathies open.
The S4 regions of all four domains of the sodium channel are involved in the voltage dependence of inactivation, demonstrating an interaction between fast and slow inactivation processes.
Kontis et al. (1997) studied this question.
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