Independent Versus Coupled Inactivation in Sodium Channels
Population
Sodium channels with a mutation substituting cysteine for the outermost arginine in the S4 segment of the…
Comparison
Chemical modification with… vs Unmodified or wild-type channels
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications for sodium channel therapies; leaves open selective modulation of activation gating in human disease models.
Structured PICO
P
Population
Sodium channels with a mutation substituting cysteine for the outermost arginine in the S4 segment of the second domain (D2:R1C)
I
Intervention
Chemical modification with methanethiosulfonate-ethyltrimethylammonium (MTSET)
C
Comparator
Unmodified or wild-type channels
O
Outcome
Voltage dependence and kinetics of activation and inactivationsurrogate
The D2/S4 segment of the sodium channel is primarily involved in channel activation rather than inactivation.
Cite This Study
Mitrović et al. (1998) studied this question.