Human heart sodium channels exhibit slower activation, inactivation, and recovery kinetics at more hyperpolarized voltages compared to skeletal muscle and brain isoforms.
No takes yet. Share an insight, caveat, or question.
hH1 kinetics differences warrant caution against isoform generalization; leaves open targeted arrhythmia research in humans.
Michael E. O’Leary (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: