Population
Xenopus oocytes expressing chimeric cardiac-skeletal calcium channel alpha 1 subunits and wild-type cardiac
Comparison
Sk1H3 chimeric construct vs Wild-type cardiac calcium channel (H4)
Design
Preclinical
Authors
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Implicates repeat I in L-type Ca channel inactivation; extends mechanistic models but leaves physiologic relevance open.
The Sk1H3 chimeric calcium channel demonstrates a prominent voltage-dependent inactivation component, suggesting repeat I plays a key role in L-type calcium channel inactivation.
Parent et al. (1995) studied this question.
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