Population
Xenopus oocytes expressing human heart Na+ channel (hH1) or rat brain IIA Na+ channels
Comparison
Coexpression with beta1/beta2 subunit chimeras… vs Expression of hH1 or IIA channels alone, or with…
Design
Preclinical
Authors
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Distinguishes beta1 domain requirements for cardiac versus neuronal Na+ channels; leaves open translation to human electrophysiology or isoform-selective therapies.
The beta1 subunit modulates cardiac and neuronal Na+ channels via different molecular interactions, with the membrane anchor playing a crucial role specifically for the cardiac isoform.
Zimmer et al. (2002) studied this question.
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