November 1, 1999Journal of Biological ChemistryOpen Access

The Extracellular Domain of the β1 Subunit Is Both Necessary and Sufficient for β1-like Modulation of Sodium Channel Gating

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Population

Xenopus oocytes expressing type IIA voltage-gated sodium Na(+) channels from rat brain

Comparison

Expression of chimeric beta1/beta2 or… vs Wild-type beta1 subunit

Design

Preclinical

Authors

KMKimberly McCormickSSM Health Care JSJayashree SrinivasanThe University of Texas at Austin KWKevin D. WhiteUniversity of South Alabama

Discussion

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Implication

May guide domain-specific Na channel modulator design; hypothesis-generating for arrhythmia therapies, pending in vivo validation.

Structured PICO

Population

Xenopus oocytes expressing type IIA voltage-gated sodium Na(+) channels from rat brain

Intervention

Expression of chimeric beta1/beta2 or beta1/myelin P0 subunits, and a truncated beta1 subunit with a glycosylphosphatidylinositol (GPI) membrane anchor

Comparator

Wild-type beta1 subunit

Outcome

Modulation of Na(+) channel gating (inactivation, recovery from inactivation, and voltage dependence)surrogate

The extracellular domain of the voltage-gated sodium channel beta1 subunit is the critical region responsible for modulating channel gating properties.

Cite This Study

McCormick et al. (1999) studied this question.

synapsesocial.com/papers/6a87cce27d1a7154c5015fea https://doi.org/10.1074/jbc.274.46.32638

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The Extracellular Domain of the β1 Subunit Is Both Necessary and Sufficient for β1-like Modulation of Sodium Channel Gating

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Extracellular Domain of the β1 Subunit Is Both Necessary and Sufficient for β1-like Modulation of Sodium Channel Gating

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider