Key result
Expression of the newly identified beta3 subunit of the voltage-sensitive sodium channel in Xenopus oocytes inactivates channel opening more slowly than the beta1 subunit.
Population
Rat pheochromocytoma cell line PC12, rat and human brain cDNA libraries, and Xenopus oocytes expressing rat…
Comparison
Coexpression of rat β3-subunit with rat… vs Expression of rat αIIA-subunit alone or…
Design
Preclinical
Authors
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May alter neuronal sodium currents distinctly from beta1; leaves open human disease relevance.
The discovery of the β3 auxiliary subunit of the voltage-sensitive sodium channel, which modulates channel gating with distinct kinetics from β1, suggests it performs a distinct neurophysiological function.
Morgan et al. (2000) studied this question. beta3 subunit expression vs. beta1 subunit was evaluated on sodium channel opening inactivation kinetics. Expression of the newly identified beta3 subunit of the voltage-sensitive sodium channel in Xenopus oocytes inactivates channel opening more slowly than the beta1 subunit.
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