Key result
A functional domain consisting of Y74, S104, Y105, and I106 residues in the extracellular loop of the β1 subunit was identified to promote voltage sensor activation and reduce intrinsic gating.
Identifies a novel extracellular domain in the β1 subunit that regulates BK channel opening through interactions with the voltage sensor and gate.
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May inform BK channel modulator design; leaves open translation from animal models to human cardiovascular applications.
Gruslova et al. (2011) studied this question. Extracellular domain of the accessory β1 subunit (Y74, S104, Y105, and I106 residues) was evaluated on BK channel voltage sensor and gate modulation. A functional domain consisting of Y74, S104, Y105, and I106 residues in the extracellular loop of the β1 subunit was identified to promote voltage sensor activation and reduce intrinsic gating.
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