Population
Large-conductance (BK-type) Ca(2+)-activated potassium channels
Comparison
beta4 subunit modulation vs alpha subunit alone
Design
Preclinical
Authors
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Hypothesis-generating for beta4 modulation of BK channels; leaves open translation to human cardiovascular physiology.
The beta4 subunit modulates BK channels via distinct opposing actions, downregulating type II BK channels at resting voltages while increasing channel opening during depolarization.
Wang et al. (2006) studied this question.
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