Key result
The beta1 subunit enhances BKCa channel Ca2+ sensitivity by stabilizing voltage sensor activation and increasing the Ca2+ dissociation constant of the closed channel from ~3.7 to 4.7-7.1 microM.
Population
Large-conductance Ca(2+)-activated K(+) channels (BK(Ca) channels)
Comparison
Presence of auxiliary beta1 subunit vs Absence of beta1 subunit
Design
Preclinical
Authors
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No immediate clinical implications from this animal model; extends molecular understanding of BKCa gating.
The beta1 subunit enhances BKCa channel Ca2+ sensitivity by stabilizing voltage sensor activation and altering the Ca2+ affinity of the closed channel.
Bao et al. (2005) studied this question. beta1 subunit vs. absence of beta1 subunit was evaluated on Mechanism of Ca2+ sensitivity enhancement. The beta1 subunit enhances BKCa channel Ca2+ sensitivity by stabilizing voltage sensor activation and increasing the Ca2+ dissociation constant of the closed channel from ~3.7 to 4.7-7.1 microM.
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