Key result
Coexpression of the beta1 subunit alters Ca2+ binding at both high-affinity sites of the BKCa channel, increasing RCK1 affinity when open and decreasing Ca2+ bowl affinity when closed.
Population
Preclinical model studying large-conductance Ca(2+)-activated potassium (BK(Ca)) channels
Comparison
Coexpression of the BK auxiliary subunit beta1… vs BK(Ca) channels without beta1 coexpression
Design
Preclinical
Authors
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May inform BKCa modulation in vascular smooth muscle; leaves open translation to human physiology or therapeutics.
The beta1 subunit increases the Ca2+ sensitivity of smooth muscle BKCa channels by modifying the Ca2+ binding affinities of the RCK1 and Ca2+ bowl sites in a state-dependent manner.
Sweet et al. (2009) studied this question. Coexpression of beta1 subunit vs. Absence of beta1 subunit was evaluated on Ca(2+) binding at high-affinity Ca(2+) binding sites. Coexpression of the beta1 subunit alters Ca2+ binding at both high-affinity sites of the BKCa channel, increasing RCK1 affinity when open and decreasing Ca2+ bowl affinity when closed.
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