Elimination of the BKCa Channel's High-Affinity Ca2+ Sensitivity

View Full Paper

Ask AI

Bookmark

Population

Large-conductance Ca(2+)-activated K(+) channel (BK(Ca))

Design

Preclinical

Authors

Discussion

Pinpoints BKCa Ca2+ binding residues in vitro; hypothesis-generating for cardiovascular K+ channel function, with no clinical implications yet.

Population

Large-conductance Ca(2+)-activated K(+) channel (BK(Ca))

Intervention

Site-directed mutations at the "Ca(2+) bowl" and M513

Outcome

High-affinity Ca(2+) response and binding characteristicssurrogate

This study identifies the specific structural sites required for the high-affinity calcium sensitivity of the BKCa channel.

Bao et al. (2002) studied this question.

View Full Paper

Ask AI

Bookmark

Pinpoints BKCa Ca2+ binding residues in vitro; hypothesis-generating for cardiovascular K+ channel function, with no clinical implications yet.