Population
Xenopus oocytes expressing the BK(Ca) alpha subunit
Comparison
Co-expression of the auxiliary beta1 subunit vs BK alpha subunit alone
Design
Preclinical
Authors
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Refines BK(Ca) gating mechanisms in animal models; leaves open whether beta1 modulation will affect human cardiovascular function.
The beta1 subunit regulates BK(Ca) channel activity primarily by reducing the intrinsic energy required for channel opening and decreasing voltage sensitivity.
Cox et al. (2000) studied this question.
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