Population
Fluorescently labeled human BK(Ca) channels (hSlo) and Shaker channels
Comparison
Coexpression with beta(2) subunits vs Channels without beta subunit coexpression and…
Design
Preclinical
Authors
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No immediate clinical implications from this animal study; extends biophysical understanding of BK(Ca) channel gating.
The beta(2) subunit of BK(Ca) channels facilitates activation by altering voltage sensor equilibrium and induces inactivation via a non-typical N-type mechanism.
Savalli et al. (2007) studied this question.
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