Population
Xenopus oocytes expressing human β3 and mouse Slo α subunits; human tissue mRNA for Northern blot analysis
Comparison
Coexpression of the novel β3 subunit with Slo α… vs Expression of Slo α subunits alone or…
Design
Preclinical
Authors
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Does not inform clinical practice; hypothesis-generating for β3 modulation of native BK channels in vivo.
The identification and characterization of the β3 subunit demonstrates a novel mechanism by which accessory subunits can finely tune the gating and rapid inactivation of BK channels.
Xia et al. (2000) studied this question.
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