Key result
The novel beta3 accessory subunit confers rapid inactivation on BK channels when coexpressed with the Slo alpha-subunit, explaining the inactivating phenotype of native BK channels in chromaffin and RIN cells.
The beta3 accessory subunit confers rapid inactivation and reduced charybdotoxin sensitivity to BK channels, explaining the native inactivating phenotype seen in adrenal chromaffin and RIN cells.
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Beta3 confers BK inactivation in endocrine cells; extends Slo diversity but leaves open cardiovascular roles.
Xia et al. (1999) studied this question. beta3 subunit coexpression vs. Slo alpha-subunit alone was evaluated on Channel inactivation properties. The novel beta3 accessory subunit confers rapid inactivation on BK channels when coexpressed with the Slo alpha-subunit, explaining the inactivating phenotype of native BK channels in chromaffin and RIN cells.
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