December 1, 2010Journal of NeuroscienceOpen Access

Modulation of BK Channel Gating by the β2 Subunit Involves Both Membrane-Spanning and Cytoplasmic Domains of Slo1

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Population

Mouse Slo1 and Drosophila Slo1 orthologs

Comparison

β2 subunit modulation vs β1 subunit modulation

Design

Preclinical

Authors

ULUrvi S. Lee JSJingyi ShiXinjiang Institute of Engineering JCJianmin CuiElectrophysiology

Discussion

Member takes

Implication

Specifies distinct structural requirements for β2 versus β1 BK modulation; extends molecular mapping but leaves open cardiovascular translation.

Structured PICO

Population

Mouse Slo1 and Drosophila Slo1 orthologs

Intervention

β2 subunit modulation

Comparator

β1 subunit modulation

Outcome

Structural domains in Slo1 critical for Ca(2+)-dependent activation and targeted by β subunitssurrogate

The β2 subunit modulates the coupling between Ca2+ binding and BK channel opening by interacting with specific structural domains in the Slo1 subunit differently than β1.

Cite This Study

Lee et al. (2010) studied this question.

synapsesocial.com/papers/6a87f3a8d03e68c3c9a52f12 https://doi.org/10.1523/jneurosci.2323-10.2010

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Implication

Specifies distinct structural requirements for β2 versus β1 BK modulation; extends molecular mapping but leaves open cardiovascular translation.

Modulation of BK Channel Gating by the β2 Subunit Involves Both Membrane-Spanning and Cytoplasmic Domains of Slo1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of BK Channel Gating by the β2 Subunit Involves Both Membrane-Spanning and Cytoplasmic Domains of Slo1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider