Population
HEK293 cells transiently transfected with mammalian (mouse or human) or Drosophila Slo1 and β2 subunits
Comparison
Co-expression of Drosophila Slo1 with β2 subunit vs Co-expression of mammalian Slo1 with β2 subunit
Design
Preclinical
Authors
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Does not inform human BK channel therapies; leaves open whether Drosophila β2 mechanisms extend to mammalian Slo1 channels.
This study reveals structural and functional differences in how the β2 subunit modulates mammalian versus Drosophila BK channels, providing insights into the mechanisms of channel activation and pre-inactivation.
Yan et al. (2016) studied this question.
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