Key result
Increasing internal Ca2+ increases dSlo mean open time, suggesting dual effects on channel gating.
Population
Cloned BK channels from Drosophila expressed in Xenopus oocytes
Comparison
Increasing internal Ca2+ concentration (Cai2+) vs Native BK channels from rat skeletal muscle
Design
Preclinical
Authors
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No immediate clinical implications for BK modulation; leaves open whether dual Ca2+ gating extends to mammalian channels.
The study suggests that Ca2+ may exert dual effects on the gating of Drosophila BK channels, requiring an expanded kinetic model compared to mammalian channels.
Moss et al. (1999) studied this question. Increasing internal Ca2+ concentration vs. Native BK channels from rat skeletal muscle was evaluated on Mean open time and Ca2+-dependent gating kinetics. Increasing internal Ca2+ concentration to 300 or 3000 microM increased dSlo mean open time, with kinetic modeling suggesting Ca2+ may exert dual effects on gating.
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