Key result
Auxiliary beta subunits of the BK channel significantly modify the channel's gating kinetics, apparent calcium sensitivity, and pharmacological responses to various natural and synthetic compounds.
Population
Large conductance voltage- and Ca-activated K channels and their α and auxiliary β subunits
Design
Review
Authors
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BK channel structure leaves open selective modulator development for vascular tone disorders; hypothesis-generating pending clinical validation.
Understanding the pharmacological modulation of BK channels via their auxiliary β subunits may provide novel therapeutic targets for diseases such as hypertension and neurological disorders.
Torres et al. (2014) reported a review. BK channel modulators was evaluated. Auxiliary beta subunits of the BK channel significantly modify the channel's gating kinetics, apparent calcium sensitivity, and pharmacological responses to various natural and synthetic compounds.
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