Current modulation and membrane targeting of the calcium channel α1C subunit are independent functions of the β subunit
Population
Transiently transfected human embryonic kidney tsA201 cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not yet inform clinical calcium channel therapies; extends mechanistic dissociation of beta subunit modulation from alpha1C trafficking in models.
Structured PICO
P
Population
Transiently transfected human embryonic kidney tsA201 cells
I
Intervention
Coexpression of rabbit cardiac muscle alpha1C (wild-type or alpha1CY467S mutant) with beta subunits (beta1a, beta2a, or beta3)
O
Outcome
Plasma membrane incorporation of channel subunits and current modulation (whole-cell and single-channel properties)surrogate
The modulation of calcium currents by beta subunits is independent of their role in targeting alpha1C subunits to the plasma membrane.
Cite This Study
Gerster et al. (1999) studied this question.