Key result
Acute application of purified β subunits to membrane vesicles doubled calcium current amplitude over 20 minutes, suggesting β subunits rapidly and reversibly modulate preexisting α1 subunits.
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Evidence suggests that calcium channel β subunits can act as rapidly reversible modulatory proteins rather than strictly invariant stoichiometric subunits.
Stephen W. Jones (2002) reported an editorial. Purified β subunits was evaluated on Calcium current amplitude. Acute application of purified β subunits to membrane vesicles doubled calcium current amplitude over 20 minutes, suggesting β subunits rapidly and reversibly modulate preexisting α1 subunits.
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