Key result
Expression of three human cardiac alpha1-isoforms in Xenopus oocytes or HEK-293 cells revealed only insignificant differences in the kinetics and voltage dependence of induced calcium-channel currents.
Population
Xenopus oocytes and HEK-293 cells expressing human cardiac L-type Ca2+-channel alpha1-subunit isoforms
Comparison
Expression of three alpha1-isoforms with or… vs Comparison among the three alpha1-isoforms
Design
Preclinical
Authors
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Similar biophysical properties across alpha1-isoforms do not support isoform-specific kinetic targeting; leaves open tissue distribution or other mechanisms in cardiac calcium handling.
Three COOH-terminal splice variants of the human cardiac L-type Ca2+-channel alpha1-subunit show differential tissue distribution but insignificant differences in biophysical properties.
Klöckner et al. (1997) studied this question. Expression of three alpha1-isoforms (hHt alpha1, rHt alpha1, fHt alpha1) was evaluated on Kinetics and voltage dependence of induced calcium-channel currents. Expression of three human cardiac alpha1-isoforms in Xenopus oocytes or HEK-293 cells revealed only insignificant differences in the kinetics and voltage dependence of induced calcium-channel currents.
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