Why the study?
Does coexpression of skeletal muscle beta and gamma subunits modulate the biophysical properties of cardiac L-type Ca2+ channels in Xenopus oocytes?
Population
Xenopus laevis oocytes expressing the cardiac Ca2+ channel alpha 1 subunit
Comparison
Coexpression with skeletal muscle beta and/or… vs Expression of cardiac alpha 1 subunit alone
Design
Preclinical
Authors
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Oocyte coexpression data require cautious extrapolation to cardiac channels; leaves open native myocyte validation.
Does coexpression of skeletal muscle beta and gamma subunits modulate the biophysical properties of cardiac L-type Ca2+ channels in Xenopus oocytes?
Heterologous skeletal muscle beta and gamma subunits can modulate the biophysical properties of cardiac alpha 1 Ca2+ channels, rather than simply amplifying their expression.
Wei et al. (1991) studied this question.
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