Population
Xenopus oocytes expressing the cardiac Ca2+ channel alpha 1C-subunit
Comparison
Coexpression of the beta-subunit with the… vs Expression of the alpha 1C-subunit alone
Design
Preclinical
Authors
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Animal data only; extends Ca2+ channel gating mechanisms but leaves open human translation.
The beta-subunit increases cardiac Ca2+ channel opening by favoring a willing mode of gating, facilitating final transitions to channel opening.
Neely et al. (1995) studied this question.
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