Why the study?
Does coexpression of the beta subunit facilitate intramolecular coupling between the voltage sensor and channel pore opening in cardiac calcium channels?
Does coexpression of the beta subunit facilitate intramolecular coupling between the voltage sensor and channel pore opening in cardiac calcium channels?
The cardiac calcium channel beta subunit facilitates intramolecular coupling between the voltage sensor and the channel pore opening.
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Clarifies beta subunit role in cardiac Ca channel gating; leaves open translation to human physiology or therapy.
The voltage-activated rabbit cardiac calcium channel alpha 1 subunit was expressed in Xenopus oocytes. The charge movement of its voltage sensor was measured and related to the opening of the ion-conducting pore. The half-activation potential for charge movement was 35 millivolts more negative than that for pore opening. Coexpression of the cardiac calcium channel beta subunit reduced this difference without affecting charge movement. Thus, intramolecular coupling between the voltage sensor and the channel pore opening can be facilitated by a regulatory subunit.
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Neely et al. (1993) studied this question.
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