Key result
Dialysis with the catalytic subunit of cAMP-dependent protein kinase increased barium currents mediated by the cardiac L-type Ca channel alpha 1 subunit up to 10-fold in CHO cells.
The alpha 1 subunit of the cardiac L-type Ca channel is sufficient for modulation by cAMP-dependent protein kinase and state-dependent phosphorylation, potentially contributing to the positive staircase effect in heart muscle.
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Alpha1 subunit enables PKA modulation of cardiac L-type Ca currents in vitro; leaves open in vivo relevance and therapeutic implications.
Sculptoreanu et al. (1993) studied this question. Dialysis with catalytic subunit of cAMP-dependent protein kinase and voltage prepulses was evaluated on Barium currents mediated by the alpha 1 subunit. Dialysis with the catalytic subunit of cAMP-dependent protein kinase increased barium currents mediated by the cardiac L-type Ca channel alpha 1 subunit up to 10-fold in CHO cells.
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